MBP and systemic lupus erythematosus: These data indicated that, as in the case of SLE monoclonal antibodies against MBP obtained by Phage display [48,49,50,51,52,53,54,55], the active centers of some monoclonal antibodies in the fractions of polyclonal MS patients’ IgGs against histones, MBP, and DNA could combine at least two activities—protease and DNase.