MBP and multiple sclerosis: Here, we have shown for the first time, using IgG–abzymes from patients with multiple sclerosis, that IgGs against H3, H1, H2A, H2B, H4, human MBP, and DNA possess an ability similar to anti-H3 IgGs to form complexes with the H3 histone, demonstrating polyreactivity in complexation.