IL6 and neoplasm: TNF-α, IL-6, and IL-17 primarily accelerate tumor progression, while cytokines normally leading to the tumor suppression include, among others, pro-apoptotic ligand inducing apoptosis associated with TNF (TRAIL, TNF-related apoptosis-inducing ligand), anti-inflammatory IL-10 and IL-12, activating cytotoxic T lymphocytes and NK cells, and regulating the expression of cytotoxic mediators [4,81].