ERBB2 and breast carcinoma: Triple-negative breast cancer (TNBC), which is defined by a lack of expression of estrogen, progesterone and HER2 (human epidermal growth factor receptor 2) receptors, accounts for 10–15% of all breast cancers and is characterized by a more aggressive tumor growth, a poorer grade of differentiation and a higher proliferation index (Ki-67), as well as a correspondingly poorer prognosis [5].