MKI67 and neoplasm: In contrast, in the multivariate Cox regression analysis adjusted for age, tumor size, axillary nodal status, histological grade of differentiation and the proliferation marker Ki-67, LAG-3 showed a significant influence on MFS (HR 0.574; 95% CI 0.369–0.894; p = 0.014) (Table 2), and a higher LAG-3 expression was associated with a longer MFS.