Chronic cerebral hypoperfusion caused an increase in the levels of sAPPα, ADAM10, and ADAM17 in the hippocampus of rats against the background of an even more significant increase in the levels of sAPPβ, BACE, and BACE1 contributed to the promotion of the amyloidogenic pathway of APP processing and caused cognitive impairment [34]. This evidence concerns the gene APP and Cognitive impairment.