In addition to the many anti-tumor functions that could be mediated by the different Fc moieties of the various Ig isotypes, the superior anti-tumor activity of the antibodies elicited by ES2B-C001 could be attributed also to their binding to multiple epitopes of HER-2 p185, resulting in a more complete inactivation of its oncogenic potential [23]. The gene discussed is EIF3A; the disease is neoplasm.