Since the discoveries in 1997 that mutations in the gene encoding α-syn (SNCA) result in an autosomal dominant form of Parkinson’s disease (PD) [1] and that it is prevalent in Lewy bodies [2], aggregates linked to disease, there have been over 10,000 original articles about this enigmatic protein (Source: Scopus, Figure 1). The gene discussed is SNCA; the disease is Parkinson disease.