Moreover, PDAC cells representing different tumor subtypes exhibited different degrees of sensitivity to pharmacological ALK2 inhibition with respect to TGFβ-driven cell invasion, with classical/epithelial COLO 357 cells being the most, and mesenchymal IMIM-PC-1 and MDA-MB-231 cells being the least, responsive. The gene discussed is ACVR1; the disease is neoplasm.