The Runt-related transcription factor 3 (RUNX3) is involved in the MET’s induction by decreasing the sensitivity to the TGF-β1-induced EMT and reversing the EMT through the TGFβ/Smad signaling and by inhibiting the invasion and migration of esophageal squamous cell carcinoma (ESCC) cells [25]. The gene discussed is TGFB1; the disease is esophageal squamous cell carcinoma.