CXCL8 and colorectal carcinoma: Overall (14 studies, 2293 patients), despite significant heterogeneity between studies (I2: 81.612), high IL-8 expression significantly correlated with worse OS in CRC patients (pooled HR by random effect model: 2.376; 95% CI 1.690–3.341; p < 0.001) (Figure 3C).