A previous meta-analysis published by Xia et al. in 2015 concluded that high IL-8 levels significantly correlated with advanced CRC stage and increased mortality risk when compared to low levels (N = 1215; pooled HR by random effect model 1.54, 95% CI 1.03–2.32) [12]. The gene discussed is CXCL8; the disease is colorectal carcinoma.