CXCL8 and colorectal carcinoma: Both IL-8 transcripts show significant increases in expression levels (Wilcoxon rank-sum test p = 3.4 × 10−13 and p = 4.6 × 10−19 for IL-8 transcript isoforms ENST00000401931.1 and ENST00000307407.3, respectively) in CRC compared to normal colon tissues (Figure 2A and Table 1).