Similarly, a significant negative impact of IL-8 expression on OS was observed in the five studies (735 patients) in which CRC patients received chemotherapy without anti-angiogenic agents (pooled HR by random effect model: 2.185; 95% CI: 1.571–3.039; p < 0.001; Figure 6C), without heterogeneity (I2: 0.000). Here, CXCL8 is linked to colorectal carcinoma.