CXCL8 and colorectal carcinoma: The relationship between high IL-8 expression and worse outcomes for advanced CRC was qualitatively similar in cohorts of patients receiving treatment with chemotherapy + anti-angiogenic agents (i.e., bevacizumab, cediranib, rogorafenib [38,41,42,43,44]), chemotherapy alone ([39,40,45]), or anti-angiogenic agents alone [44], suggesting a prognostic rather than predictive effect.