Interleukin (IL)-8 is a pro-angiogenic, pro-inflammatory C-X-C motif chemokine (CXC) ELR (Glu-Leu-Arg)+, which acts by binding to its cognate receptors (CXC receptor (CXCR) 1 and 2), two G protein-coupled receptors, expressed by both immune/stromal cells and cancer cells [7]. The gene discussed is CXCL8; the disease is cancer.