CXCL8 and colorectal carcinoma: This conclusion is further supported by the prognostic role of circulating IL-8 in surgically operated, early-stage CRC patients, in which elevated IL-8 levels were independently associated with worse PFS (HR 1.82, 95% CI 1.19–2.76) and OS (HR 2.33, 95% CI 1.32–4.11) [34].