Even in a larger population of patients (1967 for OS and 1555 for PFS) and with a different composition of contributing studies, HR for OS in our study (2.376; 95% CI 1.690–3.341) was strikingly consistent with the one reported in the study by Xia for metastatic patients, supporting the rather robust prognostic role of IL-8 in CRC, independent of the methodology used to analyze the published literature. Here, CXCL8 is linked to colorectal carcinoma.