In addition, TGFβ receptor protein expression (RI, RII) increased in the control group after TAC, while in the TRIF−/− mice, it remained at the level of the Sham-operated animals (TGFβ-RI: WT Sham = 1.00 ± 0.01, WT TAC = 1.88 ± 2.43; p = n.s; TRIF−/− Sham = 1.37 ± 1.00, TRIF−/− TAC = 0.65 ± 1.11; p = n.s.; p TAC vs. TAC = n.s.; TGFβ-RII: WT Sham = 1.00 ± 0.12; WT TAC = 1.20 ± 1.03; p = n.s.; TRIF−/− Sham = 1.13 ± 0.66; TRIF−/− TAC = 0.84 ± 0.60; p = n.s.; p TAC vs. TAC p = n.s.)(Figure 8b). The gene discussed is TGFB1; the disease is persistent truncus arteriosus.