HDM allergens induce Th2 immunity through the respiratory epithelium, resulting in the production of alarmins -IL-25, IL-33, and thymic stromal lymphopoietin (TSLP)- that stimulate release of IL-4, IL-5, and IL-13, inducing the production of sIgE, the eosinophil recruitment and survival in tissues, the production of mucus, the modulation of the airway smooth muscle contraction and airway hyperresponsiveness, finally leading to lung tissue remodeling [10,11,12]. This evidence concerns the gene TSLP and airway hyperresponsiveness.