HIV infection can elevate interleukin-1 (IL-1), IL-6, interleukin-12 (IL-12), interleukin-18 (IL-18), IFN-γ, and MCP-1, which stimulates TNF-α and -β, and the nuclear factor kappa-light-chain-enhancer of activated B cells (NFκB) [84,85,86]. The gene discussed is IL18; the disease is HIV infectious disease.