TNF and endothelial dysfunction: From a positive point of view, data are reported in studies both on mice and on humans regarding its anti-inflammatory effects, such as decreasing the levels of inflammatory cells at the arterial plaques levels, with a limited endothelial dysfunction, independent of the metabolic benefits on glucose and A1c haemoglobin (HbA1c); with a lower expression of mRNA in C reactive protein (C.R.P.)or high sensitivity C.R.P. and monocyte chemoattractant protein 1 (both in mice and human), and IL-6, ferritin, and TNF (only on studies on humans) [40,41,42,43].