YAP1 and breast carcinoma: However, its circular RNA (circYap) negatively regulates YAP translation due to its ability to bind YAP mRNA and the translation initiation proteins (eIF4G and PABP), as has been described in breast cancer where overexpression of circYap reduces YAP translation by suppressing the formation of transcriptional initiation machinery without modifying YAP mRNA levels [108].