The authors of this seminal article proposed a very interesting mechanistic comparison of inflammatory processes in patients with COVID-19 versus ARDS, sepsis and CAR T cell-induced CRS in all three important compartments (cellular, interstitial and blood), including not only cytokines but also acute phase reactants (d-dimer, CRP, ferritin, lactate dehydrogenase—LDH), as well as lymphocytes and neutrophiles. This evidence concerns the gene CRP and acute respiratory distress syndrome.