According to the literature data, NEURL2 (encodes neuralized U3-ubiquitin protein ligase 2) is a gene of the stem cells’ asymmetric division, and is involved in the self-renewal processes of mouse stemness and lung adenocarcinoma formation both in vitro and in vivo [67].The NEURL2 gene is cancer-important; it may be a biomarker for clear cell renal cell carcinoma [68], a targeted gene for colorectal cancer [69], and as a result of the expression profile analysis, it was found that the region NEURL2 gene may probably harbor a BC candidate gene [70]. The gene discussed is NEURL2; the disease is colorectal cancer.