The relation of c.-1306 C > T (rs243865) MMP2 to BC was investigated in 17 experimental studies and three meta-analyses, among which only 8 studies (7 experimental studies and one meta-analysis) proved the risk (protective) value for the disease of the allelic variant C (T) (these results are completely consistent with our data in non-obese women), whereas in the vast majority of these studies, c.-1306 C > T (rs243865) was not associated with BC (Supplementary Table S1). This evidence concerns the gene MMP2 and breast cancer.