We found in silico substantial multidirectional influences on gene expression in adipose tissue BC-related SNPs: BC risk allele A-rs3787268 in non-obese women associated with low expression NEURL2, PLTP, RP3-337O18.9, SPATA25, and ZSWIM1, whereas BC risk allele A-rs17576 in obese women associated with high expression of the same genes in visceral and/or subcutaneous adipose. Here, SPATA25 is linked to breast cancer.