PSEN1 and Huntington disease: In addition, the recent development of transgenic Göttingen minipigs have created a strong model for studying the pathology of Alzheimer’s disease (AD; amyloid precursor protein and presenilin-1 mutations) and Huntington’s disease (HD; huntingtin mutation) [5,6], while a transgenic of the Minnesota minipig has been created for cancer research (floxed line for cre-dependent tumor expression) [7].