Activation of the tumor suppressor gene early growth response (EGR) 1 and of phosphatase and tensin homolog (PTEN) and the inactivation of the AKT, the mitogen-activated protein kinase (MAPK) p38 and the wingless-integrated (Wnt)/β-catenin pathways are further anti-tumor activities of chemerin [2,3]. This evidence concerns the gene RARRES2 and neoplasm.