METTL3-induced m6A modification recruits m6A readers to stabilize hexokinase 2 (HK2) mRNA at the 3’ untranslated region, thus increasing HK2 expression and promoting the Warburg effect in esophageal carcinoma, CRC and cervical cancer [13,19]. The gene discussed is HK2; the disease is carcinoma of esophagus.