Taken together, treatment with GLP-1 receptor agonists are associated with a MACE reduction by 12%, cardiovascular death reduction by 12%, reduction in fatal or nonfatal stroke by 16%, reduction in fatal or nonfatal myocardial infarction by 9%, all-cause mortality was lowered by 12% as well as hospitalization for heart failure by 9% [42]. The gene discussed is GLP1R; the disease is myocardial infarction.