SURPASS-2 compared treatment with tirzepatide and weekly GLP-1 receptor agonist semaglutide in patients with T2DM, and found that tirzepatide was noninferior and superior to semaglutide in reduction in the hemoglobin A1c in all doses, but with much higher weight loss [9]. The gene discussed is GLP1R; the disease is type 2 diabetes mellitus.