GIP has anabolic effects on adipose tissue, reducing glucagon-mediated lipolysis and activating fatty acid synthesis, GIP inhibits osteoclastic bone resorption and induces the proliferation of osteoblasts, decreases gastrin-dependent acid secretion in the stomach, and has neuroprotective effects in Alzheimer’s disease [49,50]. The gene discussed is GIP; the disease is early-onset autosomal dominant Alzheimer disease.