Finally, dual GLP-1 and GIP receptor agonist tirzepatide reduced the risk of a composite kidney outcome (estimated GFR decline of 40% or more, renal death, progression to end-stage renal disease, or new-onset macroalbuminuria) by 41% compared to insulin glargine (HR 0.59, 95% CI 0.43–0.80). This evidence concerns the gene GLP1R and chronic kidney disease.