However, the interaction between SLC22A2 rs316019 and SLC47A1 rs2289669 in this study did not enter the model, which suggested that the interaction between SLC22A2 rs316019 and SLC47A1 rs2289669 did not significantly affect insulin resistance in patients with type 2 diabetic patients receiving metformin treatment. The gene discussed is SLC22A2; the disease is Insulin resistance.