In patients with PSA values > 3.6 ng/mL, the diagnostic performance of [18F]DCFPyL in the primary staging of PCa demonstrated a 51% detection rate for lymph node metastases (LNMs), a 56% detection rate for distant metastases, and a consequential influence on several patients’ treatment [95]. This evidence concerns the gene KLK3 and posterior cortical atrophy.