Seinost et al. [31] found a statistically significant difference in flow-mediated dilation, which was lower in patients with periodontitis compared with the Control subjects at baseline (6.1% F 4.4% vs. 8.5% F 3.4%, p = 0.002) and was improved after periodontal treatment, leading to an increase in FMD (9.8% F 5.7%; p = 0.003 vs. baseline) along with a reduced significant reduction in C-reactive protein levels. This evidence concerns the gene CRP and periodontitis.