The IHC profile of these tumors shows positivity for a range of markers: S100 (nuclear marker; sensitive for melanoma), SRY-box transcription factor 10 (SOX10; nuclear marker; highly specific for melanoma), human melanoma black 45 (HMB45; cytoplasmic marker), and Melan-A (cytoplasmic marker). This evidence concerns the gene PMEL and melanoma.