ADIPOQ and Insulin resistance: As another intervention to increase adiponectin levels in PCOS, omega-3 fatty acids were used, and a recent meta-analysis of 9 trials with 591 patients revealed an improvement of the HOMA index (homeostatic model assessment) of insulin resistance (WMD −0.80, p < 0.00001) and an increase in adiponectin levels (WMD 1.34, p = 0.002) [164].