ADIPOQ and polycystic ovary syndrome: A meta-analysis of adiponectin levels in PCOS patients, including 38 trials involving 1944 PCOS women and 1654 healthy controls, showed that its levels in all women with PCOS were significantly reduced compared to the healthy controls (WMD −2.67, 95% CI: −3.22 to −2.13; p < 0.0001) [157].