Leptin was also shown to directly impair the insulin-like growth factor 1 (IGF-1)-mediated augmentation of FSH-stimulated E2 synthesis by granulosa cells, suggesting that high leptin levels may contribute to infertility in some women with PCOS by counteracting the sensitizing effects of IGF-1 in dominant follicles [121]. This evidence concerns the gene BRD2 and polycystic ovary syndrome.