PLOD1 and polycystic ovary syndrome: In a subsequent animal study, the transplantation of BAT into a PCOS rat model activated the reduced BAT activity, and after 3 weeks could partially reverse the PCOS phenotype, including cystic follicles, leading to the normalization of ovarian steroidogenesis, and was able to reverse glucose intolerance, insulin resistance, LH levels, the FSH/LH ratio, acyclicity and infertility [213].