A major, recent meta-analysis comparing chemerin serum levels in women with and without PCOS, including 77 case-control studies with 8239 participants, reported significantly elevated circulating chemerin levels in PCOS patients with standard mean differences (SMD) of 1.87 with a 95% CI from 1.35 to 2.40 (p < 0.001) [106]. The gene discussed is RARRES2; the disease is polycystic ovary syndrome.