GNRH1 and polycystic ovary syndrome: Taken together, adiponectin and particularly HMW adiponectin, being negatively correlated both with PCOS and with hyperandrogenism, are clearly suggested to beneficially affect PCOS pathophysiology by different mechanisms, such as improving IR, the regulation of hypothalamic GnRH secretion, ovarian steroidogenesis and by promoting ovulation.