CD274 and neoplasm: Although the NPC TIME is heavily infiltrated by immune cells around and within tumor lesions [111], it is characterized by the overexpression of inhibitory immune checkpoints, such as PD-L1, LAG3, galectin 9–TIM3, TIGIT, and CTLA4, which mark exhausted CD8+ T cells and, together with Tregs, M2s, MDSCs, and inhibitory cytokines, make it immunosuppressive.