For example, in animal models of multiple sclerosis, CBD has been shown to have a significant anti-inflammatory effect since it was able to decrease the concentration of proinflammatory cytokines interleukin 6 (IL-6), interleukin 12 (IL-12), tumor necrosis factor α (TNF-α), and interleukin 1 (IL-1) [47]. This evidence concerns the gene IL6 and multiple sclerosis.