In another murine study on a model of anti-CD40 colitis, THC was also able to reduce the circulating levels of TNF-α, interleukin 17A (IL-17A), interleukin 22 (IL-22), and interferon-γ (IFN-γ), leading to a significant reduction in both systemic and local inflammation [113]. This evidence concerns the gene IL17A and colitis.