Intriguingly, in Theiler’s murine encephalomyelitis virus-induced demyelinating disease (TMEV-IDD), activation of PPAR-γ nuclear receptors by a CB agonist (WIN55,212-2) led to downregulation of intercellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) in brain endothelium. This evidence concerns the gene VCAM1 and intervertebral disk degenerative disorder.