To investigate if the inhibition of the mevalonate pathway by c-Myc inhibitor could reduce mutp53 expression and mimic the effect induced by c-Myc inhibition, we used Lovastatin, an inhibitor of the mevalonate pathway, and found that it reduced both mutp53 expression level (Figure 4B) and pancreatic cancer cell viability (Figure 4C). The gene discussed is MYC; the disease is familial pancreatic carcinoma.