TP53 and cancer: Similar to other cancers, c-Myc is frequently overexpressed and strongly drives pancreatic cell growth and proliferation [28,37], A key role in such processes is played by mutp53 [38], given that p53 gene mutations occurring in pancreatic cancer more frequently compared to other cancers may not only lead to the loss of wtp53 functions but also allow for the acquirement of oncogenic properties [12].