Tumor-microenvironment factors such as interleukin 6 (IL-6) and TGF-beta1 promote the EMT program in progressed head and neck squamous cell carcinoma (HNSCC) by targeting and activating the expression of a variety of master EMT-transcription factors (EMT-TFs) in vivo and in real patient pathologies [3,4,5]. Here, IL6 is linked to head and neck squamous cell carcinoma.