Western blot analysis confirmed that KLF4 acts as a potential MET-inducing transcription factor by suppressing the classical EMT-TF Slug in HNSCC cell line SCC-25 (Figure 5, Supplementary Document S1); furthermore, phase contrast microscopy images showed that KLF4-overexpression made originally Cisplatin-resistant HNSCC cells transiently sensitive for Cisplatin treatment in vitro. The gene discussed is SNAI2; the disease is head and neck squamous cell carcinoma.