Already, information obtained from mass spectrometry-based proteomic measurements of brain tissue is helping to understand the pathomechanism of neurodegenerative diseases such as Alzheimer’s disease [19,20] and TDP-43 proteinopathies i.e., amyotrophic lateral sclerosis [21] and fronto-temporal lobar degeneration [22]. The gene discussed is TARDBP; the disease is proteostasis deficiencies.