Most recent guidelines suggest that staging PET/CT or PET/MRI should be performed as second-line imaging in the case of doubtful cases for CI or as first-line imaging in patients with high-risk PCa (i.e., clinical T3-T4, Gleason score (GS) higher than 7 and prostate specific antigen (PSA) higher than 10 ng/mL) [4]. Here, KLK3 is linked to posterior cortical atrophy.