Additionally, previous studies determined that G5 PAMAM-PEG-Angiopep-2/TRAIL NPs and G5 PAMAM-PEG-Tf/TRAIL NPs exhibited relatively stronger accumulation in the brain tissue for brain-tumor-bearing mice and C6-glioma-bearing rats compared with in other organs [15,16]. The gene discussed is TNFSF10; the disease is central nervous system cancer.