TNFSF10 and central nervous system cancer: In C6 glioma cells, the cellular uptake behavior was observed, and the uptake amount of G5 PAMAM-PEG-Angiopep-2/TRAIL NPs and G5 PAMAM-PEG-Tf/TRAIL NPs was higher than that of naked TRAIL or brain-targeting, ligand-modified PAMAM-carried TRAIL.