NFKB1 and diffuse large B-cell lymphoma: In 2001, following the phenotypic distinction of DLBCL into subtypes that arise from B-cells at different stages of normal differentiation [7], it was found that cell lines corresponding to the activated B cell-like DLBCL (ABC-DLBCL) subtype display constitutive activation of the NF-κB pathway, although the underlying mechanism remained elusive [8].