Of note, single NikstopFLCγ1-Cre mice display overt plasma cell hyperplasia and do not succumb to tumours, suggesting that the oncogenic function of the non-canonical NF-κB pathway requires the concomitant disruption of terminal B-cell differentiation, achieved in the NikstopFLCγ1-Cre;IμHABCL6 model by deregulated BCL6 expression. The gene discussed is NFKB1; the disease is neoplasm.