In the “LymphGen” taxonomy, the ABC-DLBCL is further divided into four genetic subtypes, named after their “seed” genetic alterations: MCD (MYD88 and CD79BL265P mutations), N1 (NOTCH1 mutations), BN2 (BCL6 translocations and NOTCH2 mutations), and A53 (aneuploidy and TP53 genetic alterations). This evidence concerns the gene MYD88 and diffuse large B-cell lymphoma.