While it is possible that other genes in the amplicon represent the target of this genetic alteration, an alternative explanation for the frequent occurrence of REL amplifications in GCB-DLBCL tumour cells is that these lesions had been selected at an earlier stage of B-cell differentiation during the evolution of the “tumour-precursor cell” to a bona fide lymphoma. This evidence concerns the gene REL and diffuse large B-cell lymphoma.