Constitutive activation of the NF-κB signaling pathway is a distinctive feature of virtually all ABC-DLBCLs, originally revealed by the significant enrichment of NF-κB target genes [8] in the gene expression profiles of these lymphoma cases and by the nuclear localization of NF-κB transcription factors (RELA and p50, although p52 can also be found) in the tumour cells [11]. This evidence concerns the gene RELA and aneurysmal bone cyst.