Among all the mediators influenced after TBI, TNF-α serves as a critical regulator in acute stage neuroinflammation, triggering signaling cascades of pro-inflammatory cytokines [26], and associated with several neurodegenerative disorders, including TBI [27,28], AD [29,30], PD [31,32], multiple sclerosis (MS) [33,34], and amyotrophic lateral sclerosis (ALS) [35,36]. The gene discussed is TNF; the disease is amyotrophic lateral sclerosis.