VCP and amyotrophic lateral sclerosis: Moreover, other neurological manifestations like amyotrophic lateral sclerosis (ALS) [8], progressive spastic paraplegia [9], distal myopathy [10], facio–scapulo–humeral weakness [11], parkinsonism [6], Charcot–Marie–Tooth disease [12] and Huntington’s disease [13] have been described in association with pathogenic VCP–variants.