SIRT1 and Stroke: Raval et al. [45] and Hattori et al. [46] demonstrated that animals with a lower level of SIRT1 presented with the worst outcomes after MCA occlusion and had a larger infarct volume, associated with significantly increased acetylation levels of NF-κB, while the overexpression of SIRT1 was connected with milder degree of post-stroke damage [46,47].