In familial forms of ALS, a number of mutations in various genes have been identified, including SOD1, TAR DNA-binding protein 43 (TDP43), fused in sarcoma (FUS), ubiquilin proteins (UBQLN2), and chromosome 9 open reading frame 72 (C9ORF72) [71,72]. This evidence concerns the gene TARDBP and amyotrophic lateral sclerosis.