SIRT2 and acute myeloid leukemia: In the light of the inhibitory effects of the selected flavanones on the SIRT2 recombinant enzyme and that SIRT2 expression was increased in the M5 subtype of AML patients [7], we decided to assess their activity on a well-established cellular model of AML belonging to this subtype, as the human monocytic leukemic THP-1 cells [39].