SIRT1 and Huntington disease: Strikingly, the expression changes for the D9-Cre-Bcl11btm1.1Leid mice overlapped with expression profiles of HD mouse models, postmortem HD tissue and/or knockout mice (KO), including the genes Pde10a, Sirt1, Htra2, Npc1, and Ppargc1a (Figure 2A,B).