However, patients with CCL2 ≥ 280 pg/mL had significantly shorter VMFS than those with CCL2 < 280 pg/mL when restricted to patients who developed visceral metastasis as shown in Figure 4A. Targeting PC AR with siRNA promoted PC cell migration and metastasis via CCL2-dependent STAT3 activation and epithelial–mesenchymal transition (EMT) pathways was previously revealed [27]. Here, STAT3 is linked to pachyonychia congenita.