Indeed, after further analyses of the multi-omics datasets from Cr(VI)-transformed and control cells using the lncRNA–miRNA interaction and miRNA target prediction algorithms, three oncogenic (HOTAIRM1/miR-182-5p/ERO1A, GOLGA8B/miR-30d-5p/RUNX2, and PDCD6IPP2/miR-23a-3p/HOXA1) and three tumor suppressive (ANXA2P1/miR-20b-5p/FAM241A, MIR99AHG/miR-218-5p/GPM6A, and SH3RF3-AS1/miR-34a-5p/HECW2) lncRNA–miRNA–mRNA regulatory axes were identified. This evidence concerns the gene RUNX2 and neoplasm.