Using the same rationale, we selected three regulatory axes for tumor suppression; these axes are designated as ANXA2P1/miR-20b-5p/FAM241A (C4orf32), MIR99AHG/miR-218-5p/GPM6A, and SH3RF3-AS1/miR-34a-5p/HECW2 (Figure 4G and Table 1). The gene discussed is HECW2; the disease is neoplasm.