Some studies have focused on the associations between NLPR3 inflammasome and glaucoma, it is reported that NLRP3 inflammasome-induced release of IL-1β plays an important role in neuroinflammation and RGCs death in glaucoma and many cells and pathways participate in this process, such as microglia and NF-κβ pathway [37]. The gene discussed is NLRP3; the disease is glaucoma.