It has been reported that in the human neuroblastoma cells, accumulation of cytosolic calcium induced by hemagglutinating virus of Japan-envelope (HVJ-E) can activate RIP1 and induce necroptosis through calcium-calmodulin kinase (CaMK) II phosphorylation of RIP1 [58], which indicates that accumulation of cytosolic calcium acts as an upstream activator of RIP1. Here, RIPK1 is linked to neuroblastoma.