Perfluorinated compounds bind to nuclear receptors such as aryl hydrocarbon receptor, constitutive androstane receptor, pregnane X receptor, peroxisome proliferator-activated receptor, and farnesoid X receptor, which increase organ inflammation and oxidative stress, mitochondrial dysfunction, resulting in insulin resistance, metabolic syndrome, and liver disease [31, 32]. The gene discussed is NR1H4; the disease is metabolic syndrome.