The clinical diagnostic criteria of POF is amenorrhea together with elevated gonadotropin levels (follicle-stimulating hormone [FSH] > 20 IU/L), low estradiol (E2) levels (< 20 pg/mL), and low anti-Müllerian hormone (AMH) levels –< 0.5 ng/mL (< 1 ng/mL) [7]. Here, BRD2 is linked to premature menopause.