Dysregulation of these immune responses is central to development of COVID-19, as the combined effects of lymphopenia, reduced NK cells and CD8 + T-cells, and decreased plasmacytoid dendritic cells diminish type I IFN-mediated responses and causes a shift toward IL-8/CXCL8-induced neutrophil recruitment [126]. This evidence concerns the gene CXCL8 and lymphopenia.