Our study found that the expression of Socs3 was decreased in LPS induced ALI rats and cell models, and BUD and NAC inhibited the inflammatory factors IL-6, IL-8 and TNF-α and promote the production of IL-10 by inhibiting the targeted downregulation of Socs3 by miR-196b-5p, and alleviate LPS induced inflammatory response and lung injury. The gene discussed is TNF; the disease is acute respiratory distress syndrome.