As illustrated in Fig. 1B and C, the cross-sectional analysis demonstrated that the levels of Type I and Type III started increasing from days 15–30 (second-order model polynomial model fit curve, IFNα, R = 0.28, IFNβ, R = 0.34, IFNλ1, R = 0.39, IFNλ2, R = 0.32 and IFNλ3 R = 0.52 by Akaike’s Information Criterion) till 151 days after infection. Here, IFNL3 is linked to infection.