As shown in Fig. 2B, the levels of IFNα (GM of 456.4 pg/ml in mild, 196.3 pg/ml in severe), IFNβ (GM of 234.7 pg/ml in mild, 47.48 pg/ml in severe), As shown in Fig. 2C, IFNλ1 (GM of 1013 pg/ml in mild, 515 pg/ml in severe), IFNλ2 (GM of 961.7 pg/ml in mild, 559.1 pg/ml in severe) and IFNλ3 (GM of 382 pg/ml in mild, 241 pg/ml in severe) were significantly lower in severe than the mild COVID-19 individuals. The gene discussed is IFNL2; the disease is COVID-19.