This problem is well-illustrated by Mucopolysaccharidosis Type VI also known as Maroteaux–Lamy syndrome, in which the breakdown of glycosaminoglycans is damaged due to the deficiency in the enzyme arylsulfatase B (ARSB) caused by homozygous or compound heterozygous mutation in the ARSB gene (5q14). This evidence concerns the gene ARSB and mucopolysaccharidosis type 6.