Many of the features identified in the integrated analysis were highly penetrant across donors and subclusters, such as the peak in the proximity of AIM2 (Extended Data Fig. 6d) and the strongly enhanced AP1 motif activity (Extended Data Fig. 6e), further supporting the idea that this convergent epigenetic signature reflects a coordinated program induced in response to signals received during HCMV infection. This evidence concerns the gene FOS and cytomegalovirus infection.