We observed significant dose- and time-dependent cytotoxicity against a panel of MM cell lines, covering the most common molecular MM subtypes, with an EC50 in the range of 2–40.7 μM for the majority of MM cells, with the highest anti-tumor activity shown by As4S4/ZnS/Fe3O4 (1:4:1) with FA and Alb. This evidence concerns the gene ALB and Miyoshi myopathy.