APAF1 and Miyoshi myopathy: Cellular mechanisms triggered by 3NPs in MM decreased cell survival, which was associated with apoptotic cell death accompanied by the cleavage of caspase-3, -7, -8, and PARP, an increase in the pro-apoptotic proteins Bax and Apaf-1, and a decrease in the level of the anti-apoptotic protein XIAP.