Our results confirmed that 3NPs, with the highest anti-tumor activity shown by As4S4/ZnS/Fe3O4 (1:4:1) with FA and Alb, specifically decreased the survival of MM cells (both MM cell lines and primary patient-derived PC/MM cells) while inducing significantly less cytotoxicity on non-PC and healthy cells. This evidence concerns the gene ALB and Miyoshi myopathy.