MYC and Miyoshi myopathy: Activation of the oncogenic protein MYC, which acts as a transcription factor, is one of the central molecular events leading to MM progression, and it is manifested by several mechanisms, including translocations62,63, the gain and amplification of 8q24.21 locus2, mutations in RAS genes64, activation of MYC translation through the PI3K/AKT/mTOR pathway65, MYC transcription mediated by IRF466, and dysregulated LIN28B activity67.