Moreover, we determined the cytotoxic effects of 3NPs on acute promyelocytic leukemia cell lines (HL60, HL60-MDR1, and HL60/PLB-ABCG2 cell lines) and adenocarcinoma Caco-2 and breast cancer MCF-7 cell lines (Suppl. The gene discussed is ABCG2; the disease is acute promyelocytic leukemia.