In this study, we observed that composite NPs, namely As4S4/ZnS/Fe3O4 (1:4:1), As4S4/ZnS/Fe3O4 (1:4:1) with FA, and As4S4/ZnS/Fe3O4 (1:4:1) with FA and Alb in combination with immunomodulatory drugs, LEN or POM, showed significant synergistic anti-MM activity. Here, ALB is linked to Miyoshi myopathy.