This study investigated whether acute liver injury (ALI) persisted and identified predictors of ALI recovery [as indicated by alanine aminotransferase (ALT) level] at hospital discharge and 2 months post-discharge for 7595 hospitalized COVID-19 patients from the Montefiore Health System (03/11/2020–06/03/2021). Mild liver injury (mLI) was defined as ALT = 1.5–5 ULN, and severe livery injury (sLI) was ALT ≥ 5 ULN. Here, GPT is linked to injury.