In severe patients we found significant processes associated with cardiomyopathies, e.g. Arrhythmogenic right ventricular cardiomyopathy (FDR = 4.03E–05), Calcium signaling pathways (FDR = 4.22E–02), and immune response such as C-type leptin receptors (CLRs) (FDR = 5.67E–02) (Fig. 3a; Data S7). This evidence concerns the gene LARS1 and cardiomyopathy.